沈玉道 博士，副教授(Tenure Track)、博士生导师、独立课题组长(PI)。通过“2021beat365中国唯一官网人才引进绿色通道”加入beat365中国唯一官网，并先后入选“2021上海市海外高层次人才计划（青年）”和“2022国家海外高层次人才计划（青年）”。2007/9-2013/7 中国科学院上海有机化学研究所 有机化学 博士 导师: 李超忠研究员；2013/10-2014/8 北卡罗莱纳大学教堂山分校（University of North Carolina at Chapel Hill） 药物化学 博士后 导师: Jian Jin教授；2014/9-2019/12 西奈山伊坎医学院（Icahn School of Medicine at Mount Sinai) 药物化学 博士后 导师: Jian Jin教授；2020/1-2022/4 西奈山伊坎医学院（Icahn School of Medicine at Mount Sinai) 药物化学 讲师 导师：Jian Jin教授；2022/6-至今 beat365中国唯一官网 药物化学 。

结合有机合成和药理学技术：1. 围绕表观遗传肿瘤靶标，通过发展抑制剂和降解剂，研发临床抗肿瘤药物；2. 围绕G蛋白偶联受体，通过发展选择性激动剂，研发神经退行性和精神性疾病方面的临床药物。

发表论文：
1. Shao M., Li R., Hu J., Xi W., Mutyala R., Guan L., Huang C., Sun R., Yang X., Jin B., Zhao B., Hao E., Zhang Z., Li L., Yu X., Zhu M. *, Shen Y. * Unique Cysteine-Directed Covalent Inhibition of PRMT1 Suppresses Breast Tumorigenesis J. Med. Chem. 2026, https://doi.org/10.1021/acs.jmedchem.6c00262.
2. Peng, J.; Shao, M.; Li, Y.; Feng, J.; Zhang, X.; Xu, C.; Xie, Q.; Chen, W.; Chen, J.; Wu, D.; Bai, F.; Yao, H. *; Shen, Y. *; Meng, X.* MS1-96 induces HIP1R-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity. Acta Pharmacol. Sin. 2026, 47, 1015-1028. (共同通讯)
3. Ma, C.; Sun, H.; Shen, C.; Li, X.; Shen, Y.*, Discovery of a first-in-class protein arginine methyltransferase 1 (PRMT1) degrader for nonenzymatic functions studies. Eur. J. Med. Chem. 2025, 291, 117625.
4. Zhong, Y.; Kim, H.; Qian, C.; Xie, L.; Chen, X.; Xiong, Y.; Hu, J.; Chen, M.; Guccione, E.; Shen, Y.*; Jin, J.*, Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader. J. Med. Chem. 2025, 68 , 8543-8563.（共同通讯）
Before 2022
1. Dale, B.; Anderson, C.; Park, K-S.; Kaniskan, H.; Ma, A.; Shen, Y.; Zhang, C.; Xie, L.; Yu. X.; Jin, J. Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2. ACS Pharmacol. Transl. Sci. 2022, in press.
2. Yu, X.; Cheng, M.; Lu, K.; Shen, Y.; Zhong, Y.; Liu, J.; Xiong, Y.; Jin, J. Exploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras. J. Med. Chem. 2022, 65, 8416-8443.
3. Wu, Q.; Nie, D. Y.; Ba-Alawi, W.; Ji, Y.; Zhang, Z.; Cruickshank, J.; Haight J.; Ciamponi F. E.; Chen, J.; Duan, S.; Shen, Y.; Liu, J.; Marhon, S. A..; Mehdipour, P.; Szewczyk, M. M.; Dogan-Artun, N.; Chen, W.; Zhang, L. X.; Deblois, G.; Prinos, P.; Massirer, K. B.; Barsyte-Lovejoy, D.; Jin, J.; De Carvalho, D. D.; Haibe-Kains, B.; Wang, X.; Cescon, D. W.; Lupien, M.; Arrowsmith, C. H. PRMT inhibition induces a viral mimicry response in triple-negative breast cancer. Nat. Chem. Biol. 2022, in print.
4. Li, D.; Yu, X.; Kottur, J.; Gong, W.; Zhang, Z.; Storey, A. J.; Tsai, Y. H.; Uryu, H.; Shen, Y.; Byrum, S. D.; Edmondson, R. D.; Mackintosh, S. G.; Cai, L.; Liu, Z.; Aggarwal, A. K.; Tackett, A. J.; Liu, J.; Jin, J.; Wang, G. G. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022, in print.
5. Wang, J.; Yu, X.; Gong, W.; Liu, X.; Park, K.-S.; Ma, A.; Tsai, Y.-H.; Shen, Y.; Onikubo, T.; Pi, W.-C.; Allison, D. F.; Liu, J.; Chen, W-Y.; Cai, L.; Roeder, R. G.; Jin, J.; Wang, G. G. EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. Nat. Cell. Biol. 2022, 24, 384-399.
6. Yu, X.; Xu, J.; Shen, Y.; Cahuzac, K.; Park, K.; Dale, B.; Liu, J.; Parsons, R.; Jin, J. Discovery of potent, selective, and in vivo efficacious AKT kinase protein degraders via structure-activity relationship studies. J. Med. Chem. 2022, 65, 3644-3666.
7. Yu, X.; Xu, J.; Xie, L.; Wang, L.; Shen, Y.; Cahuzac, K.; Chen, X.; Liu, J.; Parsons, R.; Jin, J. Design, Synthesis and Evaluation of Potent, Selective and Bioavailable AKT Kinase Degraders. J. Med. Chem. 2021, 64, 18054-18081.
8. Yu, X.; Li, D.; Kottur, J.; Shen, Y.; Kim, H. S.; Park, K. S.; et al, Kaniskan, H. Ü.; Cai, L.; Jain, R.; Liu, J.; Aggarwal, A. K.; Wang, G. G.; Jin, J. A Selective WDR5 Degrader Inhibits Acute Myeloid Leukemia in Patient-Derived Mouse Models. Sci. Transl. Med. 2021, 13, eabj1578.
9. Wei, J.; Meng, F.; Park, K.; Yim, H.; Velez, J.; Kumar, P.; Wang, L.; Xie, L.; Chen, H.; Shen, Y.; Teichman, E.; Wang, G.; Chen, X.; Kaniskan, H.; Jin, J. Harnessing the E3 ligase KEAP1 for targeted protein degradation. J. Am. Chem. Soc. 2021, 143, 15073-15083.
10. Shen, Y.; Li, F.; Szewczyk, M. M.; Halabelian, L.; Chau, I.; Eram, M. S.; Dela Sena, C.; Park, K. S.; Meng, F.; Chen, H.; Zeng, H.; McLeod, D.; Zepeda-Velazquez, C. A.; Campbell, R. M.; Mader, M. M.; Watson, B. M.; Schapira, M.; Arrowsmith, C. H.; Al-Awar, R.; Barsyte-Lovejoy, D.; Kaniskan, H. U.; Brown, P. J.; Vedadi, M.; Jin, J. A First-in-class, Highly Selective and Cell-active Allosteric Inhibitor of Protein Arginine Methyltransferase 6 (PRMT6). J. Med. Chem. 2021, 64, 3697-3796. (featured article)
11. Shen, Y.; Szewczyk, M. M.; Eram, M. S.; Smil, D.; Kaniskan, H. Ü.; de Freitas, R. F.; Senisterra, G.; Li, F.; Schapira, M.; Brown, P. J.; Arrowsmith, C. H.; Barsyte-Lovejoy, D.; Liu, J.; Vedadi, M.; Jin, J. Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J. Med. Chem. 2016, 59, 9124-9139.
12. Liu, J. ; Chen, H.; Liu, Y.; Shen, Y.; Meng, F.; Kaniskan, H. U.; Jin, J.; Wei, W. Cancer selective target degradation by folate-caged PROTACs. J. Am. Chem. Soc. 2021, 143, 7380-7387.
13. Xu, J.; Yu, X.; Martin, T. C.; Bansal, A.; Cheung, K.; Lubin, A.; Stratikopoulos, E.; Cahuzac, K. M.; Wang, L.; Xie, L.; Zhou, R.; Shen, Y.; Wu, X.; Yao, S.; Qiao, R.; Poulikakos, P. I.; Chen, X.; Liu, J.; Jin, J.; Parsons, R. AKT degradation selectively inhibits the growth of PI3K/PTEN pathway mutant cancers with wild-type KRAS and BRAF by destabilizing Aurora kinase B. Cancer Discovery 2021, 11, 3064-3089.
14. Lu, S.; Neef, E.; Thomas, J.; Sabio, E.; Rousseau, B; Gigoux, M.; Knorr, D.; Greenbaurin, B.; Elhanat, Y.; Hogg , S.; Chow, A.; Ghosh, A.; Xie, A.; Zamarin, D.; Cui, D.; Erickson, C.; Singer, M.; Cho, H.; Wang, E.; Lu, B.; Durham, B.; Shah, H.; Chowell, D.; Gabel, A.; Shen, Y.; Liu, J.; Jin, Jian.; Rhodes, M.; Taylor, R.; Molina, H.; Wolchook, J.; Mergoub, T.; Diaz Jr. L.; Abdel-Wahab, O.; Bradley, R. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell 2021, 184, 4032-4047.
15. Su, H.; Jiang, M.; Senevirathne, C.; Aluri, S.; Zhang, T.; Guo, H.; Xavier-Ferrucio, J.; Jin, S.; Tran, N.; Liu, S.; Sun, C.; Zhu, Y.; Zhao, Q.; Chen, Y.; Cable, L.; Shen, Y.; Liu, J.; Qu, C.; Han, X.; Klug, C.; Bhatia, R.; Chen, Y.; Nimer, S.; Zheng, Y.; Iancu-Rubin, C.; Jin, J.; Deng, H.; Krause, C.; Xiang, J.; Verma, A.; Luo, M.; Zhao, X. Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation. Cell Reports 2021, 36, 109421.
16. Shen, Y.; Li, F.; Szewczyk, M. M.; Halabelian, L.; Park, K. S.; Chau, I.; Dong, A.; Zeng, H.; Chen, H.; Meng, F.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Brown, P.; Liu, J.; Vedadi, M.; Jin, J. Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor. J. Med. Chem. 2020, 63, 5477-5487.
17. Shen, Y.; Gao, G.; Yu, X.; Kim, H.; Wang, L.; Xie, L.; Schwarz, M.; Chen, X.; Guccione, E.; Liu, J.; Bedford, M. T.; Jin, J. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J. Med. Chem. 2020, 63, 9977-9989.
18. Shen, Y.; McCorvy, J. D.; Martini, M. L.; Rodriguiz, R. M.; Progorelov, V. M.; Ward, K. M.; Wetsel, W. C.; Liu, J.; Roth, B. L.; Jin, J. D2 Dopamine Receptor G protein-biased Partial Agonists Based on Cariprazine. J. Med. Chem. 2019, 62, 4755-4771.
19. Fong, J. Y.; Pignata, L.; Goy, P. A.; Kawabata, K. C.; Lee, S. C.; Koh, C. M.; Musiani, D.; Massignani, E.; Kotini, A. G.; Penson, A.; Wun, C. M.; Shen, Y.; Schwarz, M.; Low, D. H.; Rialdi, A.; Ki, M.; Wollmann, H.; Mzoughi, S.; Gay, F.; Thompson, C.; Hart, T.; Barbash, O.; Luciani, G. M.; Szewczyk, M. M.; Wouters, B. J.; Delwel, R.; Papapetrou, E. P.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Minden, M. D.; Jin, J.; Melnick, A.; Bonaldi, T.; Abdel-Wahab, O.; Guccione, E. Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer Cell 2019, 36, 194-209, e9.
20. Zhu, Y.; He, X.; Lin, Y. C.; Dong, H.; Zhang, L.; Chen, X.; Wang, Z.; Shen, Y.; Li, M.; Wang, H.; Sun, J.; Nguyen, L. X.; Zhang, H.; Jiang, W.; Yang, Y.; Chen, J.; Muschen, M.; Chen, C. W.; Konopleva, M. Y.; Sun, W.; Jin, J.; Carlesso, N.; Marcucci, G.; Luo, Y.; Li, L. Targeting PRMT1-Mediated FLT3 Methylation Disrupts Maintenance of MLL-rearranged Acute Lymphoblastic Leukemia. Blood 2019, 134, 1257-1268.
21. He, X.; Zhu, Y.; Lin, Y. C.; Li, M.; Du, J.; Dong, H.; Sun, J.; Zhu, L.; Wang, H.; Ding, Z.; Zhang, L.; Zhang, L.; Zhao, D.; Wang, Z.; Wu, H.; Zhang, H.; Jiang, W.; Xu, Y.; Jin, J.; Shen, Y.; Perry, J.; Zhao, X.; Zhang, B.; Liu, S.; Xue, S. L.; Shen, B.; Chen, C. W.; Chen, J.; Khaled, S.; Kuo, Y. H.; Marcucci, G.; Luo, Y.; Li, L. PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD(+) Acute Myeloid Leukemia. Blood 2019, 134, 548-560.
22. Scheer, S.; Ackloo, S.; Medina, T. S.; Schapira, M.; Li, F.; Ward, J. A.; Lewis, A. M.; Northrop, J. P.; Richardson, P. L.; Kaniskan, H. Ü.; Shen, Y.; Liu, J.; Smil, D.; McLeod, D.; Zepeda-Velazquez, C. A.; Luo, M.; Jin, J.; Barsyte-Lovejoy, D.; Huber, K. V. M.; De Carvalho, D. D.; Vedadi, M.; Zaph, C.; Brown, P. J.; Arrowsmith, C. H. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat. Commun. 2019, 10, 19.
23. Zhang, T.; Wu, J.; Ungvijanpunya, N.; Jackson-Weaver, O.; Gou, Y.; Feng, J.; Ho, T. V.; Shen, Y.; Liu, J.; Richard, S.; Jin, J.; Hajishengallis, G.; Chai, Y.; Xu, J. Smad6 Methylation Represses NFκB Activation and Periodontal Inflammation. J. Dent. Res. 2018, 7, 810-819.
24. Shen, Y.; Szewczyk, M. M.; Eram, M. S.; Smil, D.; Kaniskan, H. Ü.; de Freitas, R. F.; Senisterra, G.; Li, F.; Schapira, M.; Brown, P. J.; Arrowsmith, C. H.; Barsyte-Lovejoy, D.; Liu, J.; Vedadi, M.; Jin, J. Discovery of a Potent, Selective and Cell-active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J. Med. Chem. 2016, 59, 9124-9139.
25. Eram, M. S.;# Shen, Y.;# Szewczyk, M.; Wu, H.; Senisterra, G.; Li, F.; Butler, K. V.; Kaniskan, H. Ü.; Speed, B. A.; dela Seña, C.; Dong, A.; Zeng, H.; Schapira, M.; Brown, P. J.; Arrowsmith, C. H.; Barsyte-Lovejoy, D.; Liu, J.; Vedadi, M.; Jin, J. A Potent, Selective and Cell-active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem. Biol. 2016, 11, 772-781. (#共同一作)
26. Kaniskan, H. U.; Eram, M. S.; Liu, J.; Smil, D.; Martini, M. L.; Shen, Y.; Santhakumar, V.; Brown, P. J.; Arrowsmith, C. H.; Vedadi, M.; Jin, J. Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1). MedChemComm 2016, 7, 1793-1796.
27. Chen, X.; McCorvy, J. D.; Fischer, M. G.; Butler, K. V.; Shen, Y.; Roth, B. L.; Jin, J. Discovery of G Protein-biased D2 Dopamine Receptor Partial Agonists. J. Med. Chem. 2016, 59, 10601-10618.
发表专利：
1. Jian Jin; Jing Liu; Yudao Shen; Ernesto Guccione; Martin Walsh; Almudena Bosch; Megan Sch warz ; Protein arginine methyltransferase 5 (PRMT5) degradation/disruption compounds and methods of use for treating PRMT5-mediated diseases, 2019-8-29, WIPO, WO2019165189A1.
2. Jian Jin; Marta Filizola; Aneel Aggarwal; Samir Parekh; Abhijeet Kapoor; Shashidhar Jitian; H Kaniskan; Jianping Hu; Yudao Shen; Fanye Meng; Lihuai Qin; Yulin Han; Xufen Yu; Chengwei Zha ng; Prashasti Kumar; Rinku Jain; Clement Lee ; SOX11 inhibitors for treating mantle cell lymphoma, 2021-12-23 WIPO, WO2021257544A1.

先后发现了多个高活性、高选择性并有细胞活性的PRMTs抑制剂和降解剂，包括Type I PRMTs 抑制剂MS023； PRMT4 和PRMT6双重抑制剂 MS049；PRMT6共价抑制剂MS117；PRMT6变构抑制剂SGC6870；PRMT5降解剂MS4322。以上的一系列化学探针被发表在国际知名的药物化学期刊上，且被广泛用于动物模型研究中，并取得积极的实验结果，部分实验数据被包含发表在高影响因子的学术期刊上 (Cell (2021), Cell Reports (2021), Nature Communications (2019), Bloods (2019), Cancer Cells (2019), Bloods (2019))。其中的四个抑制剂MS023、MS049、MS117和SGC6870已被众多试剂公司作为产品销售。此外，发现了选择性激活G蛋白信号通路的多巴胺受体 (D2R) 偏向配体 MS1768。
代表作：Shen, Y.
1. Shao M., Li R., Hu J., Xi W., Mutyala R., Guan L., Huang C., Sun R., Yang X., Jin B., Zhao B., Hao E., Zhang Z., Li L., Yu X., Zhu M. *, Shen Y. * Unique Cysteine-Directed Covalent Inhibition of PRMT1 Suppresses Breast Tumorigenesis J. Med. Chem. 2026, https://doi.org/10.1021/acs.jmedchem.6c00262.
2. Peng, J.; Shao, M.; Li, Y.; Feng, J.; Zhang, X.; Xu, C.; Xie, Q.; Chen, W.; Chen, J.; Wu, D.; Bai, F.; Yao, H. *; Shen, Y. *; Meng, X.* MS1-96 induces HIP1R-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity. Acta Pharmacol. Sin. 2026, 47, 1015-1028. (共同通讯)
3. Ma, C.; Sun, H.; Shen, C.; Li, X.; Shen, Y.* Discovery of a first-in-class protein arginine methyltransferase 1 (PRMT1) degrader for nonenzymatic functions studies. Eur. J. Med. Chem. 2025, 291, 117625.
4. Zhong, Y.; Kim, H.; Qian, C.; Xie, L.; Chen, X.; Xiong, Y.; Hu, J.; Chen, M.; Guccione, E.; Shen, Y.*; Jin, J.* Discovery of a potent and selective protein arginine methyltransferase 5 (PRMT5) PROTAC Degrader. J. Med. Chem. 2025, 68, 8543-8563.（共同通讯）
5. Shen, Y.;# Li, F.;# Szewczyk, M. M.;# Halabelian, L.;# Chau, I.; Eram, M. S.; Dela Sena, C.; Park, K. S.; Meng, F.; Chen, H.; Zeng, H.; McLeod, D.; Zepeda-Velazquez, C. A.; Campbell, R. M.; Mader, M. M.; Watson, B. M.; Schapira, M.; Arrowsmith, C. H.; Al-Awar, R.; Barsyte-Lovejoy, D.; Kaniskan, H. U.; Brown, P. J.;* Vedadi, M.;* Jin, J.* A first-in-class, highly selective and cell-active allosteric inhibitor of protein arginine methyltransferase 6 (PRMT6). J. Med. Chem. 2021, 64, 3697-3796. (featured article)
6. Shen, Y.; # Gao, G.; # Yu, X.; Kim, H.; Wang, L.; Xie, L.; Schwarz, M.; Chen, X.; Guccione, E.; Liu, J.; Bedford, M. T.;* Jin, J.* Discovery of first-in-Class protein arginine methyltransferase 5 (PRMT5) degraders. J. Med. Chem. 2020, 63, 9977-9989.
7. Shen, Y.;# Li, F.;# Szewczyk, M. M.;# Halabelian, L.; Park, K. S.; Chau, I.; Dong, A.; Zeng, H.; Chen, H.; Meng, F.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Brown, P.; Liu, J.;* Vedadi, M.;* Jin, J.* Discovery of a first-in-class protein arginine methyltransferase 6 (PRMT6) covalent inhibitor. J. Med. Chem. 2020, 63, 5477-5487.
8. Shen, Y.;# McCorvy, J. D.;# Martini, M. L.; Rodriguiz, R. M.; Progorelov, V. M.; Ward, K. M.; Wetsel, W. C.; Liu, J.;* Roth, B. L.;* Jin, J.* D2 dopamine receptor G protein-biased partial agonists based on Cariprazine. J. Med. Chem. 2019, 62, 4755-4771.
9. Eram, M. S.;# Shen, Y.;# Szewczyk, M.;# Wu, H.; Senisterra, G.; Li, F.; Butler, K. V.; Kaniskan, H. Ü.; Speed, B. A.; dela Seña, C.; Dong, A.; Zeng, H.; Schapira, M.; Brown, P. J.; Arrowsmith, C. H.; Barsyte-Lovejoy, D.; Liu, J.;* Vedadi, M.;* Jin, J.* A potent, selective and cell-active inhibitor of human type I protein arginine methyltransferases. ACS Chem. Biol. 2016, 11, 772-781.（共同一作）
10. Shen, Y.;# Szewczyk, M. M.;# Eram, M. S.;# Smil, D.; Kaniskan, H. Ü.; de Freitas, R. F.; Senisterra, G.; Li, F.; Schapira, M.; Brown, P. J.; Arrowsmith, C. H.; Barsyte-Lovejoy, D.; Liu, J.;* Vedadi, M.;* Jin, J.* Discovery of a potent, selective and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6. J. Med. Chem. 2016, 59, 9124-9139.